mancozeb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt  

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2014-01-22 to 2014-01-31

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

other: UV-spectroscopy

Type:

log Pow

Temp.:

20 °C

pH:

>= 4 - <= 5

Remarks on result:

not determinable

Remarks:

at a low pH mancozeb does not tend to migrate into the water layer

Key result

Type:

log Pow

Partition coefficient:

2.3

Temp.:

20 °C

pH:

>= 6 - <= 8

Type:

log Pow

Partition coefficient:

1.8

Temp.:

20 °C

pH:

>= 9 - <= 10

Partition coefficient at pH 4-5

Ratio octanol : water	Phase	Absorbance at 281 nm	Concentration / mg/L	Pow	Mean Pow	Mean log Pow
1:1	Water 1 Water 2 Octanol 1 Octanol 2	0.0029 0.0033 0.1856 0.1878	0 0 2.961 3.001	∞ ∞	∞	∞
2:1	Water 1 Water 2 Octanol 1 Octanol 2	0.0035 0.0025 0.1907 0.1893	0 0 3.052 3.027	∞ ∞	∞	∞
1:2	Water 1 Water 2 Octanol 1 Octanol 2	0.0031 0.0032 0.1847 0.1836	0 0 2.945 2.926	∞ ∞	∞	∞
				average	∞	∞

 

Partition coefficient at pH 6-8

Ratio octanol : water	Phase	Absorbance at 281 nm	Concentration / mg/L	Pow	Mean Pow	Mean log Pow
1:1	Water 1 Water 2 Octanol 1 Octanol 2	0.0040 0.0042 0.1581 0.1550	0.008 0.011 2.472 2.417	298.71 224.91	261.8	2.4
2:1	Water 1 Water 2 Octanol 1 Octanol 2	0.0052 0.0050 0.1576 0.1591	0.023 0.021 2.463 2.490	106.64 120.71	113.7	2.1
1:2	Water 1 Water 2 Octanol 1 Octanol 2	0.0041 0.0043 0.1529 0.1523	0.010 0.012 2.380 2.369	250.19 197.71	224.0	2.4
				average	200	2.3

 

Partition coefficient at pH 9-10

Ratio octanol : water	Phase	Absorbance at 281 nm	Concentration / mg/L	Pow	Mean Pow	Mean log Pow
1:1	Water 1 Water 2 Octanol 1 Octanol 2	0.0035 0.0032 0.1907 0.1915	0.045 0.041 3.052 3.066	68.40 75.16	71.8	1.9
2:1	Water 1 Water 2 Octanol 1 Octanol 2	0.0058 0.0057 0.1917 0.1926	0.074 0.073 3.070 3.086	41.52 42.46	42.0	1.6
1:2	Water 1 Water 2 Octanol 1 Octanol 2	0.0021 0.0022 0.1857 0.1852	0.027 0.028 2.963 2.954	110.68 105.33	108.0	2.0
				average	74	1.8

Conclusions:

The log Pow of the test item was determined to be 2.3 at pH 6-8.

Executive summary:

The partition coefficient (n-octanol/water) has been determined according to OECD Guideline 107. The tests were performed in duplicate in a centrifuge tube at a temperature in the range 20 to 25 °C. The concentration of the Test Item in both layers has been determined after total separation of both phases by UV-spectroscopy according to CIPAC MT 165. The log Pow of the test item was determined to be 2.3 at pH 6-8.

Description of key information

The log Pow of the test item was determined to be 2.3 at pH 6-8.

Key value for chemical safety assessment

Log Kow (Log Pow):

2.3

at the temperature of:

20 °C

Additional information

The partition coefficient (n-octanol/water) has been determined according to OECD Guideline 107. The tests were performed in duplicate in a centrifuge tube at a temperature in the range 20 to 25 °C. The concentration of the Test Item in both layers has been determined after total separation of both phases by UV-spectroscopy according to CIPAC MT 165. The log Pow of the test item was determined to be 2.3 at pH 6-8.