Registration Dossier
Registration Dossier
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EC number: 616-995-5 | CAS number: 8018-01-7
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2014-01-22 to 2014-01-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Dissociating properties:
- no
- No.:
- #1
- pKa:
- 12.09
- Temp.:
- 20 °C
- Conclusions:
- The change of the conductivity in comparison with water due to the addition of the Test Item is negligible. No dissociation occurred.
- Executive summary:
A study was conducted according to OECD Guideline 112 to determine the dissociation constant of the test item. However, the test item has no affinity to water and will therefore not dissociate in water. The solubility in water is very low (0.2 mg/L). According to OECD Guideline 112, the dissociation constant of compounds with low solubility in water should be assessed with the spectrophotometric method or using the conductometric method. Therefore the non-dissociative character in water is verified using the conductometric method. The change of the conductivity in comparison with water due to the addition of the Test Item is negligible. No dissociation occurred. The dissociation constant has therefore been theoretical determined and calculated from the water solubility to be K = 8.2E-13.
Reference
The change of the conductivity in comparison with water due to the addition of the Test Item is negligible. No dissociation occurred. The dissociation constant has therefore been theoretical determined and calculated from the water solubility.
K = [EBDC2-] x [Me2+] = solubility mancozeb (mol/L) x solubility mancozeb (mol/L)
K= 9.07543E-07 x 9.07543E-07 = 8.2E-13
Description of key information
The change of the conductivity in comparison with water due to the addition of the Test Item is negligible. No dissociation occurred.
Key value for chemical safety assessment
Additional information
A study was conducted according to OECD Guideline 112 to determine the dissociation constant of the test item. However, the test item has no affinity to water and will therefore not dissociate in water. The solubility in water is very low (0.2 mg/L). According to OECD Guideline 112, the dissociation constant of compounds with low solubility in water should be assessed with the spectrophotometric method or using the conductometric method. Therefore the non-dissociative character in water is verified using the conductometric method. The change of the conductivity in comparison with water due to the addition of the Test Item is negligible. No dissociation occurred. The dissociation constant has therefore been theoretical determined and calculated from the water solubility to be K = 8.2E-13.
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