tert-butyl 5'-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 03 to 09 August 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Specific details on test material used for the study:

Batch/Lot number: 451021
Description: White to off white to light yellow powder
Purity: 99.1%

Key result

Water solubility:

< 0.05 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 7 - < 8

Details on results:

No test item was detected in the test samples, the concentration of the analytical samples was below 10 ng/mL. Calculating with the applied dilution (5-fold) the test item concentration in the saturation samples were below 50 ng/mL, which equals to 50 μg/L.

Conclusions:

The water solubility of the test item at 20±0.5°C is less than 50 μg/L.

Description of key information

The water solubility of the test item at 20±0.5°C is less than 50 μg/L.

Key value for chemical safety assessment

Water solubility:

0.05 mg/L

at the temperature of:

20 °C