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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

35-day NOEC based on mortality and sub-lethal effects: 0.686 mg/L
5-day NOEC based on number hatched: >9.76 mg/L (effective); read-across MDEA-Esterquat C16-18 and C18 unsatd.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.686 mg/L

Additional information

No experimental data are available for the target substance MDEA-Esterquat C18 satd. However, a long-term toxicity study in freshwater fish is available for the closely related source substance MDEA-Esterquat C16 -18 and C18 unsatd. A justification for read-across is given in the general endpoint summary Aquatic toxicity.

The 35-day chronic toxicity of MDEA-Esterquat C16-18 and C18 unsatd. to early life stages of Fathead minnow, Pimephales promelas, was studied under flow-through conditions using river water, according to US EPA TSCA, 40 CFR, Part 797.1600. Fertililized eggs (25 eggs, reduced to 15 fry after hatch) were exposed to a control and measured concentrations of 0.686, 1.41, 2.68, 5.30 and 9.76 mg/L as total activity by LSC. The test system was maintained at 25 +/- 1°C and a pH of 8.0 (7.7 to 8.3). The 35 -day NOEC values, based on mortality (post-fry reduction) and sub-lethal effects (length and weight) were 0.686 mg/L. The 5-day NOEC based on number hatched was >9.76 mg/L. Although the post-fry reduction survival did not monotonically decrease with exposure concentration, a NOEC of 0.686 mg/L could statistically be determined. Although survival in one control chamber prior to fry reduction and one control chamber at test termination was <70%, the NOEC of 0.686 mg/L met validity criteria of survival in each chamber of >70%.