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Long-term toxicity to aquatic invertebrates

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Description of key information

Daphnia magna
21-day EC50 based on mortality: 1.7 mg/L (95% confidence limits of 1.5 and 1.9 mg/L effective); read-across MDEA-Esterquat C16-18 and C18 unsatd.
21 -day NOEC based on survival, number of young/adult/reproduction day, and growth (length and weight): 1.0 mg/L; read-across MDEA-Esterquat C16-18 and C18 unsatd.
Production of offsprings in the treated groups indicated that MDEA-Esterquat had an effect on the reproduction at concentration greater than 1 mg/L.
This study is classified as reliable with restriction and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1 mg/L

Additional information

No experimental data are available for the target substance MDEA-Esterquat C18 satd. However, a long-term toxicity study in freshwater invertebrates is available for the closely related source substance MDEA-Esterquat C16 -18 and C18 unsatd. A justification for read-across is given in the general endpoint summary Aquatic toxicity.

The 21-day chronic toxicity of the structurally similar source substance MDEA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was investigated under flow-through conditions (using river water) in a study conducted according to EPA OTS 797.1330 (Daphnid Chronic Toxicity Test). Daphnids were exposed to a control and test chemical at measured concentrations of 0, 0.27, 0.47, 1.0, 2.0 and 3.9 mg/L. The 21-day EC50 based on mortality was 1.7 mg/L (95% confidence limits of 1.5 and 1.9 mg/L). The 21-day NOEC based on survival, number of young/adult/reproduction day, and growth (length and weight) was 1.0 mg/L. Production of offspring in the treated groups indicated that MDEA-Esterquat C16-18 and C18 unsatd. had an effect on the reproduction at concentration greater than 1 mg/L.