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Short-term toxicity to aquatic invertebrates

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Description of key information

Daphnia magna: 24-h EC50=14.8 mg/L (nominal; 95% C.L.: 8.4 - 26.2 mg/L); read-across MDEA-Esterquat C16-18, C18 unsatd.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
14.8 mg/L

Additional information

No experimental data are available for the target substance MDEA-Esterquat C18 satd. However, short-term toxicity studies in freshwater invertebrates are available for the closely related source substances MDEA-Esterquat C16 -18 and C18 unsatd., MDIPA Esterquat C16-18 and C18 unsatd. and MDIPA Esterquat C18 unsatd. A justification for read-across is given in the general endpoint summary Aquatic toxicity.

The 24-hr acute toxicity of MDEA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was investigated under static conditions in a study conducted according to OECD TG 202 (Part I). Daphnids were exposed to 0, 0.1, 0.32, 1.0, 3.2, 10 and 32 mg/L (nominal) for 24 hours. Immobilisation was observed at test termination. The 24-h EC50 was 14.8 mg/L with 95% CL of 8.4 - 26.2 mg/L (nominal each). No other effects were noted. The study period of 24 h was recommended before adoption of the OECD Guideline 202 in 2004. Therefore this study does not meet the time criterium (study duration 24 h instead of 48 h) of today standard methods.

Similar results were obtained with the closely related read-across substance MDIPA Esterquat C16-18 and C18 unsatd and MDIPA Esterquat C18 unsatd..:

The 48–hr-acute toxicity of MDIPA Esterquat C18 unsatd. to Daphnia magna was studied under semi-static conditions.  Daphnids were exposed to control and test chemical at nominal concentrations of 0.10, 0.32, 1.0, 3.2, 10 mg/L, corresponding to measured (TWA) concentrations of 0.077, 0.27, 0.89, 2.8 and 8.6 mg/L in the presence of 4 mg/L humic acid for 48 h.  Mortality/immobilisation and sublethal effects were observed daily. 

The 48-hour EC50 was >8.6 mg/L (TWA) based on immobilisation.  

The 48–hr-acute toxicity of MDIPA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was studied under semi-static conditions.  Daphnids were exposed to control and test chemical at analytically confirmed nominal concentrations of 0, 2.5, 4.5, 8.1, 14 and 25 mg/L in the presence of 4 mg/L (< 2mg/L DOC) humic acid for 48 h.  Immobilisation was observed daily. 

The 48-hour EC50 was 6.7 mg/L (analytically confirmed nominal concentration) based on immobilisation.