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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 JAN 2002 - 01 FEB 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
Guideline 92/69/EWG, 1992
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
4
Temp.:
25 °C
Remarks on result:
other: no pH value stated in the study report
Details on results:
Calibration data:
Regresssion: log Pow = a + b log k'
Parameters: a = - 0.7714, b = 0.3561, r = 0.987

log Pow of the test substance:
1st injection: tR = 11.26 min
2nd injection: tR = 11.25 min
3rd injection: tR = 11.25 min
mean: tR = 11.253 min
k = 4.489
logk = 0.6522
log Pow = 4.00
Conclusions:
The log Pow was found to be 4.0 (Pow = 9.96E+03).
Executive summary:
The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in guideline 92/69/EWG, appendix A.8, following GLP. The log POW was found to be 4.0 (POW = 9.96E+03).

Description of key information

The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in guideline 92/69/EWG, appendix A.8, following GLP. The log POW was found to be 4.0 (POW= 9.96E+03).

Key value for chemical safety assessment

Log Kow (Log Pow):
4
at the temperature of:
25 °C

Additional information