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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 JAN 2002 - 15 MAY 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Guideline 92/69/EEC, 1992
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Water solubility:
2.8 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
5.9

Preliminary Visual Estimation of the Water Solubility

The preliminary visual experiments showed that the water solubility of the test substance is between 10 and 20 mg/L. Therefore the water solubility had to be determined by the "flask-method", but due to the arguments mentioned in chapter (Preliminary visual estimation of the water solubility) the column-elution-method was used.

Column elution method

The coating check was successful.

According to the guideline, the data of the fractions 1 to 5 were not take into account for the following evaluation. The values for the water solubility were calculated from the fractions 14 to 18 for column 5, from fractions 7 to 12 without 10 for column 6 and from fractions 25 to 29 for column 3.

Fractions 6 to 13 for column 5, fractions 6 and 10 for column 6 and fractions 6 to 24 and 30 to the end for column 3 were discarded.

Result run 3: Evaluation of the fractions 25 to 29. The measured concentration in a 0.5-1 mL dilution was found to be < 0.05 mg/L.

Result run 5: Evaluation of the fractions 14 to 18. The water solubility was found to be 2.94 mg/L.

Result run 6: Evaluation of the fractions 7 to 12 - without 10. The water solubility was found to be 2.71 mg/L.

Conclusions:
The water solubility of the test item at a temperature of 20°C is 2.8 mg/L.
Executive summary:

The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a GLP study via the column-elution method. The water solubility of the test item at a temperature of 20°C is 2.8 mg/L.

Description of key information

The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a GLP study via the column-elution method. The water solubility of the test item at a temperature of 20°C is 2.8 mg/L.

Key value for chemical safety assessment

Water solubility:
2.8 mg/L
at the temperature of:
20 °C

Additional information