4-(4-isopropoxyphenylsulfonyl)phenol

Additional ecotoxological information

Administrative data

Endpoint:

additional ecotoxicological information

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Bisphenol A alternatives in thermal paper from the Netherlands, Spain, Sweden and Norway. Screening and potential toxicity

Author:

Maria K. Bjórnsdotter, Willem Jonker, Jessica Legradi, Jeroen Kool, Ana Ballesteros-Gómez

Year:

2017

Bibliographic source:

Science of the Total Environment 601-602 (2017) 210-221

Report date:

2017

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The developmental and neurotoxicity of the identified developers including D-8 were tested as individual compounds using zebrafish embryos.

GLP compliance:

no

Type of study / information:

Endocrine system modulation

Test material

Test material information

Constituent 1

Reference substance name:

4-(4-isopropoxyphenylsulfonyl)phenol

EC Number:

405-520-5

EC Name:

4-(4-isopropoxyphenylsulfonyl)phenol

Cas Number:

95235-30-6

Molecular formula:

C15H16SO4

IUPAC Name:

4-[4-(propan-2-yloxy)benzenesulfonyl]phenol

Specific details on test material used for the study:

Purity 98%

Results and discussion

Any other information on results incl. tables

D-8 induced phenotypical malformations at 100 µM (D-8 29 mg/L). At 24 hpf embryos showed an abnormal development and an increase in coagulated (dead) eggs was observed. At 48 hpf the number of coagulated eggs increased and at 72 hpf all embryos were dead. At 100 nM (D-8 29 µg/L) no effects on heartbeat, development or behavior could be observed.

Applicant's summary and conclusion

Conclusions:

D-8 induced phenotypical malformations, abnormal development and an increase of coagulated (dead) eggs at 29 mg/L, the highest concentration tested. At 29 µg/L no effects on development could be observed.

Executive summary:

D-8 was tested for developmental toxicity and neurotoxicity using zebrafish (Danio rerio) embryos. D-8 induced phenotypical malformations at 100 µM (D-8 29 mg/L). At 24 hpf embryos showed an abnormal development and an increase in coagulated (dead) eggs was observed. At 48 hpf the number of coagulated eggs increased and at 72 hpf all embryos were dead. At 100 nM (D-8 29 µg/L) no effects on heartbeat, development or behavior could be observed.