4-(4-isopropoxyphenylsulfonyl)phenol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988-07-11 to 1988-12-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 10

Deviations:

not specified

Principles of method if other than guideline:

The water solubility was analysed by HPLC chromatography with UV detection.

GLP compliance:

not specified

Type of method:

flask method

Key result

Water solubility:

19.7 mg/L

Temp.:

25 °C

pH:

6.85

Details on results:

The amount of D-8 is calculated based on the peak areas as follows:
Solubility (g/L) = Cs x Vs x Au x F / As x Vu
whereas
Cs : Concentration of standard solution (g/L)
Vs : Injected volume of standard solution (µL)
As : Mean of integral peak area of standard
Vu : Injected volume of sample solution (µL)
Au : Mean of integral peak area of the sample
F : Concentration/dilution factor

The pH of the filtrate was 6.85. The solubility of D-8 increased with the time as showed in the table.

At the longest saturation time of 168 hours, the mean value was 19.7E-3 g/L at 25 °C.

Table: Solubility of D-8 in Water.

Saturation time (hrs)	0	24	168
Solubility	1       * 2       15.25	18.49 16.92	19.15 20.14
(x 10^-3g/L)	Av.   15.66	17.71	19.65

* Figures are mean values of 2 measurements

Conclusions:

The solubility of D-8 in distilled water was determined according to the method CIPAC MT 10. The solubility of D-8 in distilled water was 19.7 mg/L at a pH of 6.85 and 25 °C.

Executive summary:

The solubility of D-8 in distilled water was determined according to the method CIPAC MT 10. About 3 mg of D-8 was weighed into each of six medium bottles and 50 mL of distilled water was added to each flask. They wre stoppered and immersed in an ultrasonic bath for 15 min below 30 °C. They were shaken at about 150 frequencies/min by a mechanical shaker for 40 min at 25 °C.

The flasks were kept at 25 °C for 0, 24 and 168 hours. The two of them were separately filtered through a membrane fliter (0.45.µm) under reduced pressure. About 10 mL of the initial filtrate was discarded. The rest of the filtrate was measured for pH, and 10 mL of the filtrate was pipetted into the 20 or 25 mL volumetric flask and diluted with methanol. An aliquot (10 µL) of the solution was duplicately injected into the HPLC and the amount of D-8 was calculated.

The solubility for D-8 in distilled water was 19.7 mg/L at a pH of 6.85 and 25 °C.

Description of key information

The solubility of D-8 in distilled water was 19.7 mg/L at a pH of 6.85 and 25 °C, as determined according to the method CIPAC MT 10.

Key value for chemical safety assessment

Water solubility:

19.7 mg/L

at the temperature of:

25 °C

Additional information

The solubility of D-8 in distilled water was determined according to the method CIPAC MT 10. The solubility of D-8 in distilled water was 19.7 mg/L at a pH of 6.85 and 25 °C.