Registration Dossier
Registration Dossier
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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Scientifically not justified.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 15 mg/L
Additional information
According to REACH Annex XI Section 1 (“The study is scientifically not necessary; other information available”) no study on the toxicity to microorganisms has to be conducted. Following REACH Annex XI Section 1.2 “Weight of Evidence” other information is available that is reliable and sufficient to cover the endpoint of toxicity to microorganisms according to REACH Annex VIII Section 9.1.1 Column 1. The performance of the toxicity testing of D-8 to aquatic microorganisms is scientifically not justified. D-8 was tested for ready biodegradability in a biodegradation screening test according to EU Method C.4-C and OECD 301B, and in a simulation test of biodegradation in water and sediment according to OECD Guideline 303A. In both tests, D-8 showed no signs of toxic activity to the activated sludge. Thus, it can be concluded that D-8 is non-toxic to aquatic microorganisms. Therefore, no test on toxicity to microorganisms was performed. A NOEC of 15 mg/L was chosen as a key vlaues (from the OECD 303A study) for further risk assessment.
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