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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios.
Reason / purpose for cross-reference:
read-across source
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
The source material is Isobutylquinoleine. It is a mixure of 2 isomers.
The two isomers are 6-Sec-butylquinoline and 8-sec-butylquinoline. The target substance is 6-Sec-butylquinoline.
Irritation parameter:
erythema score
Basis:
animal: #1, #2 and #3
Time point:
24/48/72 h
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 14 days
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
edema score
Basis:
animal: #1, #2 and #3
Time point:
24/48/72 h
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Animal #1: slight fissures and desiccated skin by 72 hours and scar formations by day 7; Animal #1 and #2: moderate to slight scales between day 7 to 14; Animal #3: slight scales between day 7 to 14 and desiccated skin by 72 hours
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Interpretation of results:
Category 2 (irritant) based on GHS criteria
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Conclusions:
In a skin irritation study with rabbits, performed according to OECD 404 (1981), with the source material, irritation was observed, which was fully reversible within 14 days, although scaling was still present. Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios. Based on the results of this study, the source substance is considered a skin irritant: Category 2 (H315), the target material (6-sec-butylquinoline) can also be considered a skin irritant: Category 2 (H315).
Executive summary:

The test source material was tested in a skin irritation test in 3 rabbits in accordance with OECD TG 404 (1981) test guideline and according to GLP principles. The mean value for erythema from gradings at 24, 48 and 72 hours after patch removal was 3 in all animals. For oedema, this mean value was 2 in all animals. No corrosive effect was observed. The irritation was fully reversible within 14 days, although scaling was still present. Based on the results of this study, the substance is considered a skin irritant. As source and target material are comparable, the same conclusion may be applicable for the target material 6 -sec-butylquinoline.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios.
Reason / purpose for cross-reference:
read-across source
Specific details on test material used for the study:
The source material is Isobutylquinoleine. It is a mixure of 2 isomers.
The two isomers are 6-Sec-butylquinoline and 8-sec-butylquinoline. The target substance is 6-Sec-butylquinoline.
Irritation parameter:
cornea opacity score
Remarks:
(opacity)
Basis:
animal: #1 and #2 (mean)
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
cornea opacity score
Remarks:
(opacity)
Basis:
animal: #3 (mean)
Time point:
24/48/72 h
Score:
> 0 - < 0.33
Max. score:
4
Reversibility:
fully reversible within: 48 h
Remarks on result:
other: Corneal opacity was observed, only at 24 hours, but not enough for assigning a score of 1
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
iris score
Basis:
animal: #1, #2 and #3 (mean)
Time point:
24/48/72 h
Score:
0.33
Max. score:
2
Reversibility:
fully reversible within: 48 h
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #1
Remarks:
(mean)
Time point:
24/48/72 h
Score:
1
Max. score:
3
Reversibility:
fully reversible within: 72 h
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #2
Remarks:
(mean)
Time point:
24/48/72 h
Score:
1.67
Max. score:
3
Reversibility:
fully reversible within: 7 days
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #3
Remarks:
(mean)
Time point:
24/48/72 h
Score:
1.33
Max. score:
3
Reversibility:
fully reversible within: 72 h
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritation parameter:
chemosis score
Basis:
animal: #1, #2 and #3 (mean)
Time point:
24/48/72 h
Score:
0.33
Max. score:
4
Reversibility:
fully reversible within: 48 h
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Irritant / corrosive response data:
No correction between the experimental result of tested material and the read-across target material.
Interpretation of results:
GHS criteria not met
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Conclusions:
In an eye irritation study with rabbits, performed according to OECD 405 (1981) with the source material, limited irritation was observed. Based on the results of this study, the substance does not need to be classified for eye irritation, in accordance with the CLP Regulation. Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios. Based on the results of this study, the source substance does not need to be classified for eye irritation, in accordance with the CLP Regulation. The target material (6-sec-butylquinoline) can also be considered as no eye irritation.
Executive summary:

The test source material was tested in an eye irritation test in rabbits according to OECD 405 (1981). Slight ocular effects were observed, which were fully reversible within 7 days. The cornea and iris scores were<0.33. The conjunctival redness and conjunctival oedema following grading at 24, 48 and 72 hours after installation of the substance were 2 or lower, exept one animal, which scored 3 at the 24 h only. Therefore the substance is not considered an eye irritant. As source and target material are comparable, the same conclusion may be applicable for the target material 6 -sec-butylquinoline.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification