Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios.
Reason / purpose for cross-reference:
read-across source
Specific details on test material used for the study:
The source material is Quinoleine, 6-(1-methylpropyl) (main constituent) Quinoleine, 8-(1-methylpropyl) (11-15%). It is a mixure of 2 isomers.
The two isomers are 6-Sec-butylquinoline and 8-sec-butylquinoline. The target substance is 6-Sec-butylquinoline.
Preliminary study:
From a pilot study with the substance it was concluded that the LD50 could be near or above 2000 mg/kg.
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other:
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Mortality:
No correction between the experimental result of tested material and the read-across target material.
Clinical signs:
other: No correction between the experimental result of tested material and the read-across target material.
Gross pathology:
No correction between the experimental result of tested material and the read-across target material.
Interpretation of results:
GHS criteria not met
Remarks:
No correction between the experimental result of tested material and the read-across target material.
Conclusions:
In an acute oral toxicity study with male and female rats, performed according to OECD 401 test guidelines, an LD50 >2000 mg/kg bw was determined with the source material. Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios. A LD50 > 2000 mg/kg bw can also be considered for the target material (6-sec-butylquinoline).
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification