6-sec-butylquinoline

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

4th July 2018 to 29th January 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

Version of 23th March 2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Version of 24th August 2009

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Specific details on test material used for the study:

- Name: 6-sec-butylquinoline
- Purity by GLC: > 99.2%
- Lot number: 6SBQ5/2017
- Molecular formula: C13H15N
- Molecular weight: 185.26955 g/mol

Key result

Test no.:

#1

Temp.:

303.2 K

Vapour pressure:

0.564 Pa

Key result

Test no.:

#2

Temp.:

313.2 K

Vapour pressure:

1.74 Pa

Key result

Test no.:

#3

Temp.:

323.3 K

Vapour pressure:

3.93 Pa

Conclusions:

For the test item 6-sec-butylquinoline, the following vapour pressures at 20 °C and at 25 °C
were calculated from the regression equation:
Vapour pressure at 20 °C: 0.2 Pa
Vapour pressure at 25 °C: 0.345 Pa

Executive summary:

Vapour pressure was examined at four different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p).

Experiment	T	Mean P	Stand. Dev. p	RSD p
No.	K	Pa	Pa	%
1	303.2	0.564	0.0693	12.3
2	313.2	1.74	0.325	18.6
2	323.2	3.93	0.987	25.1

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

The graph 1/T vs. log (p) shows a straight line with a correlation coefficient of - 0.9971.

For the test item 6-sec-butylquinoline, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 0.2 Pa

Vapour pressure at 25 °C: 0.345 Pa

Description of key information

For the test item 6-sec-butylquinoline, the following vapour pressures at 20 °C and at 25 °C

were calculated from the regression equation:

Vapour pressure at 20 °C: 0.2 Pa

Vapour pressure at 25 °C: 0.345 Pa

Key value for chemical safety assessment

Vapour pressure:

0.2 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of the test item 6-sec-butylquinoline was determined at four different temperatures (30, 40, 50 and 60 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Experiment 4 (nominal temperature 60 °C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.

Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 26 % and good correlation.