Reaction mass of dodecyl methacrylate and tridecyl methacrylate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar physicochemical, ecotoxicological and toxicological properties because
• they are manufactured from similar or identical precursors under similar conditions
• they share structural similarities with common functional groups: methacrylate esters
• the metabolism pathway leads to comparable products (methacrylic acid and medium chain alcohol).

Therefore, read-across from the existing physicochemical, ecotoxicity and toxicity studies on the source substances is considered as an appropriate adaptation to the standard information requirements of REACH regulation

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
see “Justification for read-across” attached to IUCLID section 13

3. ANALOGUE APPROACH JUSTIFICATION
see “Justification for read-across” attached to IUCLID section 13

4. DATA MATRIX
see “Justification for read-across” attached to IUCLID section 13

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across: supporting information

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

> 10 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Description of key information

An OECD 203 guideline GLP study with nominal test concentrations above 10000 mg/L showed no toxicity to Danio rerio.
Therefore, it appears that saturated solutions are non-toxic to fish. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

10 000 mg/L

Additional information

No experimental data are available for the target substance Reaction mass of dodecyl methacrylate and tridecyl methacrylate. However, a toxicity study in Danio rerio was conducted with the closely related source substance Isotridecyl methacrylate. A justification for read-across is given in the endpoint summary "Aquatic toxicity".

LC50 [96 h] > 10000 mg / L

Concentrations used in the available test are five orders of magnitude above the water solubility of Isotridecyl methacrylate, which is < 1 µg/L. Therefore, emulsions or even two-layer systems of the test item with water have been tested instead of solutions setting a limitation to the validity of the study. However, it appears that saturated solutions of the substance are non-toxic to fish.