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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar physicochemical, ecotoxicological and toxicological properties because
• they are manufactured from similar or identical precursors under similar conditions
• they share structural similarities with common functional groups: methacrylate esters
• the metabolism pathway leads to comparable products (methacrylic acid and medium chain alcohol).

Therefore, read-across from the existing physicochemical, ecotoxicity and toxicity studies on the source substances is considered as an appropriate adaptation to the standard information requirements of REACH regulation

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
see “Justification for read-across” attached to IUCLID section 13

3. ANALOGUE APPROACH JUSTIFICATION
see “Justification for read-across” attached to IUCLID section 13

4. DATA MATRIX
see “Justification for read-across” attached to IUCLID section 13
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across: supporting information
Test organisms (species):
activated sludge
Test type:
static
Duration:
5 d
Dose descriptor:
EC0
Effect conc.:
> 500 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Executive summary:

No inhibition of respirometric activity in any of the tested concentrations. LC0 (bacteria): > 500 mg/L in emulsion according to OECD guideline 209.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

5 d LC0 > 500 mg/L (equivalent to OECD TG 209, RL1, GLP)

Key value for chemical safety assessment

EC50 for microorganisms:
500 mg/L

Additional information

No experimental data are available for the target substance Reaction mass of dodecyl methacrylate and tridecyl methacrylate. However, activated sludge respiration inhibition tests are available for the closely related source substances Dodecyl methacrylate and Methacrylic acid methyl ester 13.6. A justification for read-across is given in the endpoint summary "Aquatic toxicity".

 

In a 5 d toxicity study according to OECD Guideline 209 the cultures of activated sludge were exposed to Dodecyl methacrylate at concentrations of 100, 200 and 500 mg/L. Due to low solubility the substance was tested emulsified.

No inhibition of respirometric activity in any of the tested concentrations. LC0 (bacteria): > 500 mg/L.

 

In a 3 h toxicity study according to OECD Guideline 209 the cultures of activated sludge were exposed to Methacrylic acid methyl ester 13.6 at a concentration of 10000 mg/L. The EC10 (3 h) was > 10000 mg/L. Therefore, it can be concluded that the test substance Methacrylic acid methyl ester 13.6 is non-toxic to bacteria.