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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
441-070-6
EC Name:
-
Cas Number:
61826-76-4
Molecular formula:
C14H11NO2
IUPAC Name:
(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

Test animals

Species:
rat
Strain:
other: Crl:CD(SD)IGS BR
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
Doses:
200 and 2000 mg/kg bw
No. of animals per sex per dose:
200 mg/kg bw: 3 males and 3 females
2000 mg/kg bw: 3 males
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 500 - <= 1 000 mg/kg bw
Based on:
test mat.
Mortality:
Male: 200 mg/kg bw: Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw: Number of animals: 3; Number of deaths: 0
Male: 2000 mg/kg bw: Number of animals: 3; Number of deaths: 2
Clinical signs:
other: -Signs of toxicity related to dose levels: Sedation and righting reflex catalepsy at both doses. Dyspnoea and motor excitation only at 2000 mg/kg bw. Signs were observed shortly after application until a maximum of 5 days.
Gross pathology:
Effects on organs: Gastrointestinal alterations and oedema in the lungs, at 2000 mg/kg bw. Probable cause of death: gastrointestinal lesions.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In an acute oral toxicity study in rats conducted according to OECD guideline 423, the LD50 was found to be in the range of 500 to 1000 mg/kg bw.
Executive summary:

In an acute oral toxicity study in rats conducted according to OECD guideline 423, the LD50 was found to be in the range of 500 to 1000 mg/kg bw.