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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
441-070-6
EC Name:
-
Cas Number:
61826-76-4
Molecular formula:
C14H11NO2
IUPAC Name:
(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: 6.5 x 8 cm
- % coverage: 10%
- Type of wrap if used: cellulose patch with the claculated amount of test substance was applied to the test site and held in place by fixing marginally with non-irritating tape.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, residual test substance was wiped off using wet cellulose tissue
- Time after start of exposure: 24 hours
Duration of exposure:
24 hours
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred
Clinical signs:
other: Only eschar formation at the administration site and chromodacryorrhoea were recored for 2 males and 2 females and lasted until a maximum of 8 days
Gross pathology:
No adverse effects

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute dermal toxicity study conducted according to OECD guideline 402, rats were dermally treated with the test item. Based on the results, the LD50 can be considered to be greater than 2000 mg/kg bw.
Executive summary:

In an acute dermal toxicity study conducted according to OECD guideline 402, rats were dermally treated with the test item. Based on the results, the LD50 can be considered to be greater than 2000 mg/kg bw.