p-benzoquinone dioxime

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

The principles of the method would be generally in accordance with the US 16 CFR 1500.3 definitions. (jurisdiction where the test was conducted).

Deviations:

yes

Remarks:

Absence of gross pathology and/or assessment in the other sex - not deemed to impact reliability of the study.

Principles of method if other than guideline:

- Principle of test: The principles of the method would be generally in accordance with the US 16 CFR 1500.3 definitions. (jurisdiction where the test was conducted).
- Short description of test conditions: According to US CFR 1500.3: the test would be conducted on 10 laboratory white rats (weighing between 200 and 300 grams), and the LD50 would be determined to determine the toxicity class.
- Parameters analysed / observed: Lethality and clinical signs

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

p-benzoquinone dioxime

EC Number:

203-271-5

EC Name:

p-benzoquinone dioxime

Cas Number:

105-11-3

Molecular formula:

C6H6N2O2

IUPAC Name:

N-[(1Z,4Z)-4-(hydroxyimino)cyclohexa-2,5-dien-1-ylidene]hydroxylamine

Details on test material:

- Name of test material (as cited in study report): para-benzoquinone dioxime

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not reported.
- Age at study initiation: Not reported.
- Weight at study initiation: 200 - 300 g according to US CFR 1500.3 defintiions
- Fasting period before study: Not reported
- Housing: Not reported.
- Diet: rat chow ad libitum (details Not reported).
- Water: ad libitum
- Acclimation period: Not reported.

ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported.
- Humidity (%): Not reported.
- Air changes (per hr): Not reported.
- Photoperiod (hrs dark / hrs light): Not reported.

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

No. of animals per sex per dose:

10 (details on sex not specified)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days according to US CFR 1500.3 definitions.
- Frequency of observations and weighing: At least once daily for 14 days.
- Necropsy of survivors performed: No.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

464 mg/kg bw

Based on:

test mat.

Mortality:

Mortalities occurred.

Clinical signs:

other: Details of toxic effects not reported other than lethal dose value

Gross pathology:

Not examined

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Remarks:

EU criteria met

Conclusions:

Under the conditions of this study the LD50 was determined to be 464 mg/kg bw in the rat.

Executive summary:

The study was performed following a method equivalent or similar to OECD TG 401 to assess the acute oral toxicity potential of the test substance to rats. The test item was administered as a single oral dose to group of 10 male rats orally. Under the conditions of this study the LD50 was determined to be 464 mg/kg bw.