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Diss Factsheets

Administrative data

vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May-June 2018
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guidelineopen allclose all
according to guideline
OECD Guideline 104 (Vapour Pressure Curve)
according to guideline
EU Method A.4 (Vapour Pressure)
GLP compliance:
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate
EC Number:
EC Name:
Sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate
Cas Number:
Molecular formula:
sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate
Test material form:
solid: particulate/powder
Details on test material:
Batch 44034
Description: Cream to light grey powder
Expiry date: 30 November 2019
Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%).
Specific details on test material used for the study:
Storage Conditions at Test Facility:
At 20 °C ± 5°C, in the dark

Test Item Preparation (GLP)
The test item is solid and was suspended with acetone. The glass plate with the test sample was subsequently dried at room temperature.

Results and discussion

Vapour pressure
Key result
Test no.:
20 °C
Vapour pressure:
0.559 Pa

Any other information on results incl. tables

Plot of the evaporation rate versus temperature (1000/T) temperature range of 80 °C to 110 °C (Test Item)

y = -1.9936x + 2.1834

The coefficient of correlation (R2) was 0.9702.

Calibration of the reference items : y = 1.0022x + 4.3781

The coefficient of correlation (R2) was 0.9825.

Applicant's summary and conclusion

The isothermal thermogravimetric effusion method was applied for the determi-nation of the vapour pressure of Isomethol.
A value of the vapour pressure of the test item was determined using the data obtained between 70 °C and 110 °C. The vapour pressure of the test item was calculated (mean of three determinations) to: 5.59 x 10-1 Pa at 20 °C.
Executive summary:

The evaluation of the vapour pressure was done with the re-producible weight loss values above ≥ 1 μg/min in the temperature range be-tween 80 °C to 110 °C (below the melting point).

The resulting equation was:

log PT=4.3781+1.0022∙log VT

Inserting the equation for log VT above, the following equation for the temperature dependence of the vapour pressure of the test item is obtained:

log PT=C+D x (a x 1000/T +b)= C+(D x b)+(D x a x 1000 )/T

(where: a = -1.9936, b =2.1834, C = 4.3781 and D = 1.0022)

With this equation, a following vapour pressure results were obtained: 5.59 x 10-1 Pa at 20 °C.