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Physical & Chemical properties

Particle size distribution (Granulometry)

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Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2016-04-14 to 2016-06-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Version / remarks:
1981
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: NF ISO 2591-1
Version / remarks:
1989
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: NF X11-507
Version / remarks:
1989
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
sieving
Remarks:
Manual and mechanical sieving
Type of particle tested:
other: Solid item
Type of distribution:
mass based distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Osalmid
EC Number:
208-385-9
EC Name:
Osalmid
Cas Number:
526-18-1
Molecular formula:
C13H11NO3
IUPAC Name:
2-hydroxy-N-(4-hydroxyphenyl)benzamide
Test material form:
solid: particulate/powder
Remarks:
White or off-white crystalline powder

Results and discussion

Mass median aerodynamic diameter:
>= 45 - <= 355 µm
Geometric standard deviation:
ca. 0.019
Particle sizeopen allclose all
Key result
Percentile:
other: Particle size distribution of the majority of the particles (99.9%)
Mean:
<= 1 mm
St. dev.:
0.002
Remarks on result:
other: Preliminary test
Key result
Percentile:
other: Particle size distribution
Mean:
>= 45 - <= 355 µm
St. dev.:
0.019
Remarks on result:
other: Main test
Particle size distribution at different passagesopen allclose all
No.:
#1
Size:
>= 710 µm
Distribution:
0.2 %
No.:
#2
Size:
>= 500 - <= 710 µm
Distribution:
0.2 %
No.:
#3
Size:
>= 355 - < 500 µm
Distribution:
0.9 %
No.:
#4
Size:
>= 250 - < 355 µm
Distribution:
12.3 %
No.:
#5
Size:
>= 180 - < 250 µm
Distribution:
19.7 %
No.:
#6
Size:
>= 125 - < 180 µm
Distribution:
11.4 %
No.:
#7
Size:
>= 100 - < 125 µm
Distribution:
5.9 %
No.:
#8
Size:
>= 90 - < 100 µm
Distribution:
8.8 %
No.:
#9
Size:
>= 63 - < 90 µm
Distribution:
22.8 %
No.:
#10
Size:
>= 45 - < 63 µm
Distribution:
16.3 %
No.:
#1
Size:
>= 32 - < 45 µm
Distribution:
ca. 1.2 %
No.:
#2
Size:
>= 25 - < 32 µm
Distribution:
0.1 %
No.:
#3
Size:
>= 20 - < 25 µm
Distribution:
0 %
No.:
#4
Size:
< 20 µm
Distribution:
0.2 %

Any other information on results incl. tables

The loss of mass recorded in the principal sieving was 1.9%.

A graph of the Cumulated Undersized Particles of the test item can be seen in the "attached Illustration section"

Applicant's summary and conclusion

Conclusions:
After the preliminary test, it was shown that the majority of the particles (99.9%) had a size lower than 1 mm.
After the main test, it was shown that the particle size distribution of the test item was found to range approximately 45 μm to 355 μm.