Registration Dossier
Registration Dossier
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EC number: 208-385-9 | CAS number: 526-18-1
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Remarks:
- QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
VEGA (version 1.1.3)
2. MODEL (incl. version number)
Fish Toxicity classification Model version 1.0.2
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
O=C(Nc1ccc(O)cc1)c2ccccc2(O)
For SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL, APPLICABILITY DOMAIN and ADEQUACY OF THE RESULT please see the attached document "Fish Toxicity classification Model version 1.0.2" in the field "Attached justification" where the QMRF is explained.
Data source
Reference
- Title:
- VEGA v.1.1.3
- Year:
- 2 016
- Bibliographic source:
- Fish Toxicity classification Model version 1.0.2
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Please see the attached document before in the section 'Attached justification'
Test material
- Reference substance name:
- Osalmid
- EC Number:
- 208-385-9
- EC Name:
- Osalmid
- Cas Number:
- 526-18-1
- Molecular formula:
- C13H11NO3
- IUPAC Name:
- 2-hydroxy-N-(4-hydroxyphenyl)benzamide
- Test material form:
- solid: particulate/powder
- Remarks:
- White or off-white crystalline powder
Constituent 1
- Specific details on test material used for the study:
- SMILE: Oc1c(C(=O)Nc2ccc(O)cc2)cccc1
Log Kow: 2.466
Results and discussion
Effect concentrations
- Dose descriptor:
- LC50
- Effect conc.:
- >= 10 - <= 100 mg/L
- Remarks on result:
- other: Predicted toxicity class 3
- Details on results:
- Structural alerts: Toxicity class 3 alert no. 13; Toxicity class 3 alert no. 24
- Reported statistics and error estimates:
- The predicted compound is into the Applicability Domain of the model
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Prediction is Toxic-3 (between 10 and 100 mg/l), the result appears reliable. Anyhow, you should check it through the evaluation of the information given in the following sections.
The following relevant fragments have been found: Toxicity class 3 alert no. 13; Toxicity class 3 alert no. 24
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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