Registration Dossier
Registration Dossier
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EC number: 208-385-9 | CAS number: 526-18-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE: VEGA (version 1.1.3)
2. MODEL (incl. version number): Mutagenicity (Ames test) CONSENSUS model 1.0.1
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
O=C(Nc1ccc(O)cc1)c2ccccc2(O)
For SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL, APPLICABILITY DOMAIN and ADEQUACY OF THE RESULT please see the attached document "Mutagenicity Consensus Guide" in the field "Attached justification" where the QMRF is explained.
Cross-reference
- Reason / purpose for cross-reference:
- (Q)SAR model reporting (QMRF)
Data source
Reference
- Title:
- VEGA version 1.1.3
- Year:
- 2 016
- Bibliographic source:
- Mutagenicity (Ames test) CONSENSUS model 1.0.1
Materials and methods
Test guideline
- Guideline:
- other: Mutagenicity (Ames test) CONSENSUS model 1.0.1
- Type of assay:
- other: QSAR prediction
Test material
- Reference substance name:
- Osalmid
- EC Number:
- 208-385-9
- EC Name:
- Osalmid
- Cas Number:
- 526-18-1
- Molecular formula:
- C13H11NO3
- IUPAC Name:
- 2-hydroxy-N-(4-hydroxyphenyl)benzamide
- Test material form:
- solid: particulate/powder
- Remarks:
- White or off-white crystalline powder
Constituent 1
- Specific details on test material used for the study:
- SMILES : O=C(Nc1ccc(O)cc1)c2ccccc2(O)
Results and discussion
Test results
- Key result
- Species / strain:
- not specified
- Additional information on results:
- Prediction is NON-Mutagenic with a consensus score of 0.15, based on 4 models.
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Applicant's summary and conclusion
- Conclusions:
- Prediction is NON-Mutagenic with a consensus score of 0.15 (low reliability), based on 4 models.
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