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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
>= 0.646 - <= 2.42
Temp.:
25 °C
pH:
ca. 7.9
Conclusions:
The partition coefficient of the test item has been determined to be in the range 2.58 to 7.68 x 104, log10 Pow of 0.41 to 4.89. For approximately 88% of the test item by peak area normalisation the partition coefficient was in the range 2.58 to 144, log10 Pow of 0.41 to 2.16.
Executive summary:

In the range 2.58 to 7.68 x 104, log10 Pow of 0.41 to 4.89, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

For approximately 88% of the test item by peak area normalisation the partition coefficient was in the range 2.58 to 144, log10 Pow of 0.41 to 2.16.

Description of key information

The partition coefficient of the test item has been determined in the range 4.42 to 262,  log10 Pow 0.646 to 2.42.  

Key value for chemical safety assessment

Additional information