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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxy-3-methylcyclopent-2-enone
EC Number:
201-303-2
EC Name:
2-hydroxy-3-methylcyclopent-2-enone
Cas Number:
80-71-7
Molecular formula:
C6H8O2
IUPAC Name:
2-hydroxy-3-methylcyclopent-2-en-1-one
Specific details on test material used for the study:
Purity 99.2%, Solid. The test article was suspended in standard suspending vehicle by means of a homogenizer. Homogeneity of the test article in the vehicle was maintained during treatment using a magnetic stirrer.

Test animals

Species:
rat
Strain:
other: SPF
Sex:
female
Details on test animals or test system and environmental conditions:
Number of animals: 20
Body weight at treatment start: 110-124
Age at treatment start: about 6weeks
General condition: Air-condition room
Air-temperature: 20-24 degree
Relative air humidity: 45-65%
Light cycle: Artificial light for 12 hours and darkness for 12 hours per day
Diet: NAFAG standard rat maintenance diet, No. 850
water: tap water

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Standard suspending vehicle
Details on oral exposure:
The animials were weighed and then the test article was adminstered on a mg/kg body weight base in a single dose by gavage using a stomach tube. Fee was again presented approximately 3 hours after dosing
Doses:
500, 900, 1100 or 1300 mg/kg.
No. of animals per sex per dose:
1
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 1 067.4 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria