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EC number: 201-303-2 | CAS number: 80-71-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-hydroxy-3-methylcyclopent-2-enone
- EC Number:
- 201-303-2
- EC Name:
- 2-hydroxy-3-methylcyclopent-2-enone
- Cas Number:
- 80-71-7
- Molecular formula:
- C6H8O2
- IUPAC Name:
- 2-hydroxy-3-methylcyclopent-2-en-1-one
Constituent 1
- Specific details on test material used for the study:
- Purity 99.2%, Solid. The test article was suspended in standard suspending vehicle by means of a homogenizer. Homogeneity of the test article in the vehicle was maintained during treatment using a magnetic stirrer.
Test animals
- Species:
- rat
- Strain:
- other: SPF
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Number of animals: 20
Body weight at treatment start: 110-124
Age at treatment start: about 6weeks
General condition: Air-condition room
Air-temperature: 20-24 degree
Relative air humidity: 45-65%
Light cycle: Artificial light for 12 hours and darkness for 12 hours per day
Diet: NAFAG standard rat maintenance diet, No. 850
water: tap water
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Standard suspending vehicle
- Details on oral exposure:
- The animials were weighed and then the test article was adminstered on a mg/kg body weight base in a single dose by gavage using a stomach tube. Fee was again presented approximately 3 hours after dosing
- Doses:
- 500, 900, 1100 or 1300 mg/kg.
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 067.4 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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