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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08 March 2017 - 25 April 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-ethoxyandrosta-3,5-dien-17-one
EC Number:
619-264-9
Cas Number:
972-46-3
Molecular formula:
C21H30O2
IUPAC Name:
3-ethoxyandrosta-3,5-dien-17-one
Test material form:
solid: particulate/powder
Details on test material:
Physical appearance: white crystalline powder
Test item storage: In refrigerator (2-8°C)

Results and discussion

Water solubility
Key result
Water solubility:
22.8 µg/L
Conc. based on:
test mat.
Temp.:
19.9 °C
pH:
>= 8 - <= 8.1
Remarks on result:
other: average of two runs (maximum difference= 27%)
Details on results:
Mean concentration in the water samples (n=10) obtained at the flowrate of 25 mL/h was 25.8 μg/L. CV= 5.9%.
Mean concentration in the water samples (n=10) obtained at the flowrate of 12 mL/h was 19.7 μg/L. CV= 6.0%.

The coefficient of variation (CV) (n=10) was ≤ 30% at both flow rates. It demonstrated that the system was in equilibrium at all flow rates.

The maximum difference on the mean values at both flow rates was ≤ 30%.

Any other information on results incl. tables

No test substance was detected in the samples from the blank column.

Applicant's summary and conclusion

Conclusions:
The water solubility at 19.9°C was determined to be 22.8 μg/L.
Executive summary:

The water solubility of the substance was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.

Quantification was performed by UPLC-MS/MS. The water solubility at 19.9°C was determined to be 22.8 μg/L. The pH of the aqueous samples was 8.0 -8.1.