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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From October 1997 to March 1998
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
EU Method A.8 (Partition Coefficient - Shake Flask Method)
GLP compliance:
Type of method:
flask method
Partition coefficient type:
Analytical method:
photometric method
Key result
log Pow
Partition coefficient:
< -2
25 °C
Remarks on result:
other: pH not determined
Details on results:
Average Pow = 0.000015
Standard deviation = 0.0000082
Decadic logarithm of the average Pow = - 4.8
Because very low log Pow values such as -4.8 may exhibit remarkable errors, the final results is given as log Pow = < -2.
Under the study conditions, the log Pow was of <-2 (average Pow = 0.000015).
Executive summary:

A study was conducted to determine the partition coefficient of the test substance by the shake-flask method according to EU Method A.8, in compliance with GLP. The analytical method used was photometry. Under the study conditions, the log Pow was < -2 (average Pow = 000015) (Grosenick, 1997).

Description of key information

The partition coefficient was determined by the shake-flask method according to EU Method A.8 (Grosenick, 1997).

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
25 °C

Additional information

< -2