Ethylene di(S-thioacetate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

1-h inhalation study with GDMA mist

GLP compliance:

no

Remarks:

GLP was not mandatory at the time of study

Test type:

traditional method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ethylene di(S-thioacetate)

EC Number:

204-653-4

EC Name:

Ethylene di(S-thioacetate)

Cas Number:

123-81-9

Molecular formula:

C6H10O4S2

IUPAC Name:

ethane-1,2-diyl bis(sulfanylacetate)

Specific details on test material used for the study:

not specified

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

inhalation: mist

Type of inhalation exposure:

whole body

Vehicle:

air

Remark on MMAD/GSD:

not reported

Details on inhalation exposure:

Total weight of compound used: 2.7 g
Air flow rate: 20 L/min
Duration: 60 min
Total air: 1200 L
Nominal conc.: 2.25 mg/L
Avg. chamber temperature: 20 °C

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 2.25 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Effect levels 2

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.563 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: calculated using Haber's law

Mortality:

none

Clinical signs:

other: decreased activity, laboured breathing, lacrimation, nasal discharge

Body weight:

no effect

Gross pathology:

9/10 lungs showed few scattered red or grey foci

Applicant's summary and conclusion

Interpretation of results:

other: H335: May cause respiratory irritation.

Conclusions:

With an estimated 4-h LC50 of >0.563 mg/L, GDMA may be classified as Acute Tox 3, H331: Toxic if inhaled. As no animal died in the study, the classification as toxic would not be appropriate. Because the animals showed symptoms of irritation of the lungs, H335: May cause respiratory irritation was used instead of H331: Toxic if inhaled.