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EC number: 203-674-6
CAS number: 109-46-6
Tables of results: Carcinogenicity study in mice with DETU
1/ Analyses of the incidence of primary tumors at specific
sites in female mice treated with DETU
Low dose (250 ppm)
Hematopoietic system :
Leukemia or malignant lymphoma
weeks to first observed tumor
Uterus: Endometrial stromal polyp
2/ Analyses of the incidence of primary tumors at specific
sites in male mice treated with DETU
Lung: Alveolar/Bronchiloar adenoma or alveolar/bronchiolar carcinoma
Circulatory system: Hemangioma or hemangiosarcoma
Liver: Hepatocellular carcinoma
Liver: Hepatocellular carcinoma or hepatocellular adenoma
* Significative difference between treated and control groups
(cochran-Armitage est supported by a Fischer exact test)
Study was performed to determine whether DETU have the capacity to
produce cancer in animals.
Mice were exposed to DETU in diet during 103 weeks at 250 and 500 ppm
(12.5 and 25 mg/kg bw/d respectively).
No mortality, no clinical signs were observed during this study, but
decrease of body weight gain was observed at each dose.
In both sexes, the neoplasms observed were similar in type and
distribution in dosed and control mice (ex: alveolar/bronchiolar
adenoma, hepatocellular adenoma and carcinoma, leukemia or malignant
lymphoma...). None of statistical tests for any site revealed a
significant positive association between administration of compound and
increased tumor incidence.
The severity and incidence of non-neoplastic lesions were also not
unusual (ex: pneumonia, spleen hyperplasia...).
The test substance was considered as not carcinogenic in B6C3F1 mice.
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