Registration Dossier
Registration Dossier
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EC number: 203-674-6 | CAS number: 109-46-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: 3c: Unsuitable test system.
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryotoxicity of industrial chemicals on the chicken embryo: Thiourea derivatives
- Author:
- Korhonen A., Hemminki K, Vainio H.
- Year:
- 1 982
- Bibliographic source:
- Acta pharmacol. et toxicol., 1982; 51: 38-44.
Materials and methods
- Type of study / information:
- Type: other: in vitro test, on chicken embryo
Test material
- Reference substance name:
- 1,3-dibutyl-2-thiourea
- EC Number:
- 203-674-6
- EC Name:
- 1,3-dibutyl-2-thiourea
- Cas Number:
- 109-46-6
- Molecular formula:
- C9H20N2S
- IUPAC Name:
- 1,3-dibutyl-2-thiourea
- Details on test material:
- TS-Freetext:
- Source: from the rubber factory of Oy Nokia Ab, Nokia, Finland.
- Batch number: no data
- Purity: no data
Constituent 1
Results and discussion
Any other information on results incl. tables
PARAMETERS ASSESSED DURING STUDY:
- Test substance caused early deaths but no malformation and no late death.
- The number of early deaths increased with the concentration range:
. 0 % at 0.13 µmol/egg,
. almost 50 % at 0.25 µmol/egg,
. almost 75 % at 0.50 µmol/egg
. and around 100 % at 0.75 and 1.0 µmol/egg.
CALCULATED PARAMETERS:
ED50, total effect
= LD50, total mortality
= LD50, dead not malformed
= LD50 early deaths
= 0.28 µmol/egg (with 95 % confidence limits: 0.24-0.34 µmol/egg)
=> Strong embryotoxic (embryolethal)
Applicant's summary and conclusion
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