Registration Dossier
Registration Dossier
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EC number: 203-674-6 | CAS number: 109-46-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: 3c: Unsuitable test system.
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryotoxicity of industrial chemicals on the chicken embryo: Thiourea derivatives
- Author:
- Korhonen A., Hemminki K, Vainio H.
- Year:
- 1 982
- Bibliographic source:
- Acta pharmacol. et toxicol., 1982; 51: 38-44.
Materials and methods
- Type of study / information:
- Type: other: in vitro test, on chicken embryo
Test material
- Reference substance name:
- 1,3-dibutyl-2-thiourea
- EC Number:
- 203-674-6
- EC Name:
- 1,3-dibutyl-2-thiourea
- Cas Number:
- 109-46-6
- Molecular formula:
- C9H20N2S
- IUPAC Name:
- 1,3-dibutyl-2-thiourea
- Details on test material:
- TS-Freetext:
- Source: from the rubber factory of Oy Nokia Ab, Nokia, Finland.
- Batch number: no data
- Purity: no data
Constituent 1
Results and discussion
Any other information on results incl. tables
PARAMETERS ASSESSED DURING STUDY:
- Test substance caused early deaths but no malformation and no late death.
- The number of early deaths increased with the concentration range:
. 0 % at 0.13 µmol/egg,
. almost 50 % at 0.25 µmol/egg,
. almost 75 % at 0.50 µmol/egg
. and around 100 % at 0.75 and 1.0 µmol/egg.
CALCULATED PARAMETERS:
ED50, total effect
= LD50, total mortality
= LD50, dead not malformed
= LD50 early deaths
= 0.28 µmol/egg (with 95 % confidence limits: 0.24-0.34 µmol/egg)
=> Strong embryotoxic (embryolethal)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
