1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-N-tridecylnaphthalen-2-amine

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Sept - April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

> 6.5

Temp.:

25 °C

Remarks on result:

other: Limit Value only

Remarks:

Test item did not elute from column

Details on results:

Only a minor component was detected in the partition coefficient study. Additional analytical work and method devlopment concluded that major component of Solvent Red 19T is too apolar to be focused on the column, therefore is not detectable using a HPLC method. The log Pow of Solvent Red 19T is considered to be higher than 6.5; this was confirmed by results of additional studies.The additional studies demonstrated that the test item could not be eluted from the column under the conditions of this study. Hence it is concluded that the log Pow of the test item is > 6.5.

Conclusions:

The Log Pow of Solvent Red 19T is >6.5

Executive summary:

An attempt was made to measure the partition coefficient (log Pow) of Solvent Red 19T using high performance liquid chromatography in accordance with OECD method 117.

Only a minor component was detected in the partition coefficient study.  Additional analytical work and method devlopment concluded that major component of Solvent Red 19T is too apolar to be focused on the column, therefore is not detectable using a HPLC method. The log Pow of Solvent Red 19T is considered to be higher than 6.5; this was confirmed by results of additional studies.The additional studies demonstrated that the test item could not be eluted from the column under the conditions of this study. Hence it is concluded that the log Pow of the test item is > 6.5.

This is also consistent with QSAR predictions using the Episuite KOWWIN software which predicts a value of 14.42 for the main structural component. A value of >6.5 will be used for the CSR.

Description of key information

An attempt was made to measure the partition coefficient (log Pow) of Solvent Red 19T using high performance liquid chromatography in accordance with OECD method 117. The main component could not be detected, therefore it was concluded that the Log Pow was >6.5

Key value for chemical safety assessment

Log Kow (Log Pow):

6.5

at the temperature of:

25 °C

Additional information

An attempt was made to measure the partition coefficient (log Pow) of Solvent Red 19T using high performance liquid chromatography in accordance with OECD method 117.

Only a minor component was detected in the partition coefficient study.  Additional analytical work and method devlopment concluded that major component of Solvent Red 19T is too apolar to be focused on the column, therefore is not detectable using a HPLC method. The log Pow of Solvent Red 19T is considered to be higher than 6.5; this was confirmed by results of additional studies.The additional studies demonstrated that the test item could not be eluted from the column under the conditions of this study. Hence it is concluded that the log Pow of the test item is > 6.5.

This is also consistent with QSAR predictions using the Episuite KOWWIN software which predicts a value of 14.42 for the main structural component. A value of >6.5 will be used for the CSR.