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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- no
- Other quality assurance:
- other: ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Remarks:
- also A2LA
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- 79.6 °C
- Atm. press.:
- 101.3 kPa
- Decomposition:
- no
- Key result
- Melting / freezing pt.:
- 107.5 °C
- Atm. press.:
- 101.3 kPa
- Decomposition:
- no
- Key result
- Melting / freezing pt.:
- 128.4 °C
- Atm. press.:
- 101.3 kPa
- Decomposition:
- no
- Conclusions:
- Pentamid KH displayed no freezing point evident for the sample on cooling. A possible glass transition was evident on heating. The average onset of the transition was at 37.3°C. Three average melting points were found at 79.6°C, 107.5°C, and 128.5°C.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2014 August - 2017 May
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- Experimental methods using nationally accepted methods.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Principles of method if other than guideline:
- Melting: Capillary method with liquid bath or block.- Principle of test:
Capillary method
- Short description of test conditions: Sample was loaded into a capillary tube and heated to a plateau temperature ~10 degrees below the expected melting point in a Stuart SMP20 melting point apparatus. Temperature was increased by a constant rate until the sample began to melt. Record the range at which the sample melted. Benzoic acid was used as a standard.
- Parameters analysed / observed: Temperature, physical state of substance. - GLP compliance:
- no
- Type of method:
- capillary method
- Key result
- Melting / freezing pt.:
- >= 120 - <= 133 °C
- Atm. press.:
- 101.3 kPa
- Decomposition:
- no
- Remarks on result:
- other: no data on decomposition
- Remarks:
- not noted to decompose
- Conclusions:
- Various samples of the commercial test substance was observed to melt over the range of 120 to 133 °C at approximately 101.3 kPa.
Referenceopen allclose all
Date | Batch Number | Melting Point (°C) |
19/08/2014 | 43040 | 124 |
12/05/2015 | 44673 | 128 |
04/08/2015 | 45219 | 128.4 |
09/05/2016 | 46679 | 129.1 |
09/05/2016 | 46680 | 126.3 |
09/05/2016 | 46681 | 133 |
14/11/2017 | 47652 | 120 |
18/05/2017 | 48654 | 126.1 |
18/05/2017 | 48655 | 129.6 |
18/05/2017 | 48656 | 130 |
18/05/2017 | 48657 | 130 |
Description of key information
No melting/freezing point observed in a DSC study
Key value for chemical safety assessment
Additional information
There was no freezing point evident for the sample on cooling. A possible glass transition was evident on heating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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