Registration Dossier
Registration Dossier
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EC number: 239-620-3 | CAS number: 15571-48-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- This report is a compilation of data from eye irritation studies obtained from the literature. Studies were required to have been carried out according to OECD guideline 405 and GLP to be included in this report.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Propan-2-ol
- EC Number:
- 200-661-7
- EC Name:
- Propan-2-ol
- Cas Number:
- 67-63-0
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Propanol-(2) (2-propanol, isopropyl alcohol )
- Substance type: organic
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: not reported
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- single administration
- Observation period (in vivo):
- 10 days
- Number of animals or in vitro replicates:
- 4
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Modified maximum average score
- Basis:
- mean
- Time point:
- other: 1 day
- Score:
- ca. 30.5
- Max. score:
- 110
- Reversibility:
- fully reversible
- Remarks:
- 10 days
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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