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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 13, 1997 - February 5, 1998
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Reference substance name:
SP 6012
IUPAC Name:
SP 6012
Details on test material:
See attached study report for details

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female
Details on test animals or test system and environmental conditions:
See attached study report for details

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
See attached study report for details
Duration of exposure:
1, 2.5, 4 hours, and 14 day observations. See attached study report for details.
Doses:
5,000 mg/kg bw (single dose)
No. of animals per sex per dose:
5 males/ 5 females per single dose level
Control animals:
not required
Details on study design:
See attached study report for details
Statistics:
None required for study

Results and discussion

Preliminary study:
LD50 > 5000 mg/kg bw
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
No deaths occurred during the course of the study
Clinical signs:
other: Test material produced moderate to severe dermal irritation
Gross pathology:
See attached study report for details
Other findings:
See attached study report for details

Any other information on results incl. tables

See attached study report for details

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
Estimated dermal LD50 for males and females is > 5,000 mg/kg bw
Executive summary:

See attached study report for details