Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-205-4
CAS number: -
Results of the homogeneity analysis indicate that the test material was
homogenous in the vehicle and stable for ten days when stored under
ambient conditions. Concentration analysis confirmed that the test
material was at the appropriate concentration in the dosing solutions.
A one-generation study was performed in line with OCED Guideline 415 to
determine the effects of benzenesulfonic acid, C14 -C24 branched &
linear alkyl derivs. calcium salts on rats.
Male and female rats were dosed with the test material once a day, 7
days a week for 70 days premating (males) and 14 days premating
(females). One male was then mated to one female from the same group
until evidence of mating was observed. All F0 males were dosed until
parturition and all F0 females were dosed through to day 20 of
lactation. Detailed clinical and cage side observations were performed.
Body weights and food consumption were weighed at appropriate intervals
throughout the study. Offspring were potentially exposed to the test
material in utero and via lactation. Surviving F0 dams were necropsied
on lactation day 21 and surviving males were necropsied at the
conclusion of parturition. Organ weights were determined and
microscropic examinations conducted for all surviving control and high
dose F0 animals. Sperm was collected from all surviving F0 males and
appropriate parameters determined.
On lactaion day 4, each litter was randonly culled to a maximum of 8
pups/litter (4/sex/litter where possible). Detailed pup examinations and
individual pup weights were determined throughout the lactation period.
All surviving pups at lactation day 21 were examined macroscopically.
F0 males exhibited a dose-related increase in post-dosing salivation and
dark material around the nose in the mid and high dose groups. No
effects were observed in any of the other parameters measured. No
treatment-related findings were noted in the F1 pups during lactation.
Based on the results of this study, it has been concluded that the 500
mg/kg/day dose level was the NOAEL for parental F0 and F1 pup toxicity
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again