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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Title:
FATAL POISONING WITH ZINC HEXAFLUOROSILICATE (VOGEL-FLUAT®)
Author:
Greyer H, Bergmann I, 1-Ientschel H.
Year:
2004
Bibliographic source:
EAPCCT XXIV INTERNA TlONAL CONGRESS, 01 -04 June 2004 Strasbourg

Materials and methods

GLP compliance:
no
Test type:
other: case studies
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: human
Sex:
female
Details on test animals and environmental conditions:
51-year-old female, additionally 21 cases (7 children, 14 adults) in case series

Administration / exposure

Route of administration:
oral: drinking water
Details on oral exposure:
51-year-old female: 50 mL solution with an unknown amount of VogelFluat
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD100
Based on:
not specified
Remarks on result:
not determinable
Mortality:
100%
Clinical signs:
unconsciousness, cardiovascular shock, and respiratory depression

Applicant's summary and conclusion

Conclusions:
Clinical presentation and treatment of poisoning with zinc hexafluorosilicate correspond to sodium fluoride.
Executive summary:

Case report: A 51-year-old woman ingested about 50 ml solution with an unknown amount of VogelFluat®. She was admitted to hospital two hours later with unconsciousness, cardiovascular shock, and respiratory depression. Cardiac monitoring showed irregular rhythm with atrioventricular block turning into ventricular fibrillation about four hours after ingestion. Oesophagogastroscopy confirmed the burn of distal oesophagial and gastric mucosa with discolouration to black. Cornea was also burned by ascending vapours at the moment of drinking. Chest X-ray was without pathologic findings. Laboratory findings proved metabolic acidosis (serum pH 7.0; serum bicarbonate 8 mmol/L), and hypocalcaemia (0.3 mmol/L). Calcium gluconate was given but the serum calcium level couldn't be stabilised. Resuscitative measures were done over three hours without success.

Case series: From 1994 to 2003 our poison centre recorded 21 cases (7 children, 14 adults) of zinc hexafluorosilicate exposures. Majority of cases (81%) was accidental with small amounts without symptoms. A 2-year-old child suffered from metabolic acidosis, hypocalcaemia, hyperglycaemia ( 18.0 mmoi/L), ventricular fibrillation, and seizures after ingestion of "washing powder" but survived. Mistakes without dangerous consequences (use instead of curing agent and salt for icy roads, respectively) were reported twice. In two cases the ingestion was suicidal with fatality. Conclusion: Clinical presentation and treatment of poisoning with zinc hexafluorosilicate correspond to sodium fluoride. Death has been reported in adults after ingestion of 1-2 g after 3-4 hours as result of cardiac fibrillation. The prognosis of severe suicidal poisoning is unfavourable.

References: Krämer M, Giebelmann R. Tödli che Intoxikationen mit Zinkhexafluosilikat. Dt Gesundh.-Wesen 1975; 30:2057-2059.