Registration Dossier
Registration Dossier
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EC number: 240-894-1 | CAS number: 16871-71-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 11.12 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Additional information
The NOAEL value is stated as Fluoride and not as zinc hexafluorosilicate.
Justification for classification or non-classification
The available information from repeated dose toxicity studies as well as reproductive toxicity studies do not indicate a hazard for female reproduction in relation to exposure to fluoride. A recent two-generation study focussing on the damage to the male reproductive system, no testicular effects were seen at an exposure level of 250 mg NaF/L. Additionally, it is especially noted that in none of the animal carcinogenicity studies effects on morphology ofany of the reproductive organs were found.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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