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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 09, 2017 to March 06, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181: Solubility in organic solvents
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- The study was conducted in a facility which operates in accordance with Good Laboratory Practice principles; however no claim of GLP compliance was intended nor is made for this study
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 35.5 g/L
- Temp.:
- 20 °C
- Test substance stable:
- not determined
- Conclusions:
- Under study conditions, the n-octanol solubility of the test substance, was determined to be in range of 35.5 g/L at 20.0 ± 0.5°C.
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, at 20˚C, according to CIPAC MT 181 (solubility in organic solvents). The preliminary estimate of the octanol solubility at 20.0 ± 0.5 °C was >4.9 g/L. The mean of the definitive test tested at 50 g/L adn 60 g/L using adapted flask method was determined to be 35.5 g/L at 20.0 ± 0.5°C. Under study conditions, the n-octanol solubility of the test substance, was determined to be 35.5 g/L at 20.0 ± 0.5°C (Envigo, 2018).
Reference
Results:
Preliminary Test (MT 181)
The recorded observations for the contents of the cylinder after each addition ofn-octanol are shown in the following table:
Total Volume of n-Octanol Added (mL) |
Saturation Concentration (g/L) |
Observations |
0.5 |
204 |
Opaque, white liquid with excess test item present |
1 |
102 |
Transparent, colorless liquid with excess test item present |
2 |
51.1 |
Transparent, colorless liquid with excess test item present |
3 |
34.0 |
Transparent, colorless liquid with excess test item present |
4 |
25.5 |
Transparent, colorless liquid with excess test item present |
5 |
20.4 |
Transparent, colorless liquid with excess test item present |
10 |
10.2 |
Transparent, colorless liquid with excess test item present |
The solubility was estimated to beless than 10g/L anddefinitivetesting was continued using theadapted flask method.
Preliminary Test(Adapted Flask Method): The preliminary estimate of the octanol solubility at 20.0 ± 0.5 °C was >4.9 g/L
Definitive Test(Adapted Flask Method)
The mean peak areas relating to the 50 g/L loading ratesolutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 1.53 x 103mg/L |
4.4995 x 107 |
Standard 1.23 x 103mg/L |
3.5024 x 107 |
Standard 1.02 x 103mg/L |
2.8600 x 107 |
Standard 767 mg/L |
1.7926 x 107 |
Standard 516 mg/L |
1.0730 x 107 |
Standard 256 mg/L |
3.6005 x 106 |
Standard 102 mg/L |
9.2100 x 105 |
Matrix blank |
None detected |
Sample 1A |
1.6185 x 107 |
Sample 1B |
1.5962 x 107 |
Sample 2A |
1.9103 x 107 |
Sample 2 B |
1.8515 x 107 |
The mean peak areas relating to the 60 g/L loading ratesolutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 1.54 x 103mg/L |
4.6078 x 107 |
Standard 1.23 x 103mg/L |
3.2912 x 107 |
Standard 1.03 x 103mg/L |
2.6134 x 107 |
Standard 769 mg/L |
1.7527 x 107 |
Standard 506 mg/L |
9.9511 x 106 |
Standard 256 mg/L |
3.7553 x 106 |
Standard 103 mg/L |
9.0987 x 105 |
Matrix blank |
None detected |
Sample 4A |
1.6873 x 107 |
Sample 4B |
1.7022 x 107 |
Sample 5A |
1.4424 x 107 |
Sample 5 B |
1.4969 x 107 |
Sample 6A |
1.4872 x 107 |
Sample 7B |
1.4873 x 107 |
Description of key information
The n-octanol solubility of the test substance was determined according to CIPAC MT 181: solubility in organic solvents (Envigo, 2018).
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 35.5 g/L
Additional information
Value used for CSA: 35.5 g/L at 20°C
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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