Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
The vapour pressure of the test substance was determined using the static method according to EU Method A.4 (Chilworth, 2017) as well using QSAR models, EPI Suite and TEST (US EPA, 2018).
- Experimental VP = 159 Pa at 20 °C (static method); suspected to be influenced by trapped impurities.
- Weighted average QSAR based VP = 2.64E-09 Pa at 25°C (EPI Suite v.4.11) and 3.11E-04 Pa at 25°C (T.E.S.T. v4.2.1).The estimates for the major constituents were considered to be reliable with restrictions, as they do not completely fall within the applicability domain.
- Experimental VP of similar TMACs: VP values ranged from 2.64E-9 to <0.0058 Pa at25°C (Refer to the data matrix of the category justification)
Overall, based on the above information, the test substance, C18 -22 TMACcan be considered to have low volatility. However, in absence of a reliable experimental value, the higher QSAR based VP value of 3.11E-04Pa has been considered further for hazard/risk assessment as a conservative approach.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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