Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

short-term repeated dose toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
Reason / purpose for cross-reference:
data waiving: supporting information

The vapour pressure of the test substance was determined using the static method according to EU Method A.4 (Chilworth, 2017) as well using QSAR models, EPI Suite and TEST (US EPA, 2018).

Vapour pressure:
0 Pa
at the temperature of:
25 °C

- Experimental VP = 159 Pa at 20 °C (static method); suspected to be influenced by trapped impurities.

- Weighted average QSAR based VP = 2.64E-09 Pa at 25°C (EPI Suite v.4.11) and 3.11E-04 Pa at 25°C (T.E.S.T. v4.2.1).The estimates for the major constituents were considered to be reliable with restrictions, as they do not completely fall within the applicability domain.

- Experimental VP of similar TMACs: VP values ranged from 2.64E-9 to <0.0058 Pa at25°C (Refer to the data matrix of the category justification)

Overall, based on the above information, the test substance, C18 -22 TMACcan be considered to have low volatility. However, in absence of a reliable experimental value, the higher QSAR based VP value of 3.11E-04Pa has been considered further for hazard/risk assessment as a conservative approach.

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion