Registration Dossier
Registration Dossier
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EC number: 265-314-4 | CAS number: 65036-46-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Flask method
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 336.43 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 5 000 g/L
- Incubation duration:
- > 1 - < 3 d
- Temp.:
- 20 °C
- pH:
- > 5.82 - < 5.93
- Conclusions:
- The water solubility of test item “Direct Yellow 147” was performed according to OECD 105 (1995) and EPA Test Guideline OCSPP 830.7840 by an HPLC-UV method. The analytical method used for the analyte quantification proved to be specific and linear. The water solubility of 2.5 g of “Direct Yellow 147” at 20°C in 5.0 mL of water with flask method proved to be 336.43 g/L. An additional test was performed using the worst case scenario, as described in guidelines. The result
corresponds to about 98% of recovery with respect to the theoretical initial amount of sample in solution, so as verified for the working solutions of the final test. Therefore the result of water solubility is strictly related to the amount of substance used to perform the test and the content of water added. - Executive summary:
336.43 g/L
Reference
Description of key information
In an OECD 105 study performed on the registered substance, the water solubility measured by HLPC was 336.43 g/L.
Key value for chemical safety assessment
- Water solubility:
- 336.43 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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