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Environmental fate & pathways

Biodegradation in water: screening tests

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Link to relevant study record(s)

Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
Read-across from the alternative salt form of the registered substance is justified. Please see the justification document in section 13.
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 835.3110 (Ready Biodegradability)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: International Standard ISO 9439: Water Quality - Evaluation in an aqueous medium of the "ultimate" aerobic biodegradability of organic compounds - Method by analysis of released carbon dioxide.
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge, domestic, non-adapted
Duration of test (contact time):
28 d
Initial conc.:
20 mg/L
Based on:
TOC
Remarks:
corresponds to approximately 43 mg/L test substance
Parameter followed for biodegradation estimation:
CO2 evolution
Key result
Parameter:
% degradation (CO2 evolution)
Value:
>= 20 - <= 30
Sampling time:
28 d
Interpretation of results:
not readily biodegradable
Conclusions:
The substance is not biodegradable based on a screening test on the read-across substance.

Description of key information

>20 - <30 % biodegradation was observed during 28 days in an OECD 301 study with the read-across substance.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed
Type of water:
freshwater

Additional information

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