Potassium tetrahydroborate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

The study is well documented following general scientific practice.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Animals were fasted for 24 hours, then given a single calcuated dose and placed in a cage for a two week observation period.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium tetrahydroborate

EC Number:

241-004-4

EC Name:

Sodium tetrahydroborate

Cas Number:

16940-66-2

Molecular formula:

BH4.Na

IUPAC Name:

Sodium tetrahydridoborate(1–)

Details on test material:

- Name of test material (as cited in study report): Sodium borohydride powder
- Physical state: powder
- Lot/batch No.: 3-97

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 150-250 g
- Fasting period before study: 24 hours
- Housing: screen bottom cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not reported


ENVIRONMENTAL CONDITIONS: not reported

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 250 mg/ml

Doses:

50, 100 and 1000 mg/kg

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no

Statistics:

not reported

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

100 mg/kg bw

Remarks on result:

other: LD50 for sodium tetrahydroborate

Mortality:

No animals died at 50 mg/kg; 3/6 animals died at 100 mg/kg within one hour; 6/6 animals died at 1000 mg/kg within one minute.

Clinical signs:

no data

Body weight:

no data

Gross pathology:

not applicable

Other findings:

not reported

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

The acute oral LD50 for sodium tetrahydroborate was determined to be 100 mg/kg.