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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
The study is well documented following general scientific practice.
Qualifier:
no guideline available
Principles of method if other than guideline:
Animals were fasted for 24 hours, then given a single calcuated dose and placed in a cage for a two week observation period.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 150-250 g
- Fasting period before study: 24 hours
- Housing: screen bottom cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not reported


ENVIRONMENTAL CONDITIONS: not reported


Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 250 mg/ml
Doses:
50, 100 and 1000 mg/kg
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
Statistics:
not reported
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
100 mg/kg bw
Remarks on result:
other: LD50 for sodium tetrahydroborate
Mortality:
No animals died at 50 mg/kg; 3/6 animals died at 100 mg/kg within one hour; 6/6 animals died at 1000 mg/kg within one minute.
Clinical signs:
no data
Body weight:
no data
Gross pathology:
not applicable
Other findings:
not reported
Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
The acute oral LD50 for sodium tetrahydroborate was determined to be 100 mg/kg.
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
The inorganic salts sodium tetrahydroborate as well as potassium tetrahydroborate are highly soluble in water. The toxicity is determined by the tetrahydroborate moiety of the salt as both sodium and potassium are known to be non-toxic. Thus a read-across approach to a reliable experimental study with sodium tetrahydroborate is sufficient to cover this endpoint.
Reason / purpose for cross-reference:
read-across source
Qualifier:
no guideline available
Principles of method if other than guideline:
Animals were fasted for 24 hours, then given a single calcuated dose and placed in a cage for a two week observation period.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 150-250 g
- Fasting period before study: 24 hours
- Housing: screen bottom cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not reported


ENVIRONMENTAL CONDITIONS: not reported


Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 250 mg/ml
Doses:
50, 100 and 1000 mg/kg
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
Statistics:
not reported
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
100 mg/kg bw
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
145 mg/kg bw
Remarks on result:
other: LD50 for potassium tetrahydroborate by molecular weight correction
Mortality:
No animals died at 50 mg/kg; 3/6 animals died at 100 mg/kg within one hour; 6/6 animals died at 1000 mg/kg within one minute.
Clinical signs:
no data
Body weight:
no data
Gross pathology:
not applicable
Other findings:
not reported
Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
The acute oral LD50 was determined to be 100 mg/kg.
By molecular weight correction the LD50 for potassium tetrahydroborate is 145 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
145 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification