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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 03 January 2018 to 31 January 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
EC Number:
615-206-1
Cas Number:
709031-45-8
Molecular formula:
C6H10N2O.CH4O3S
IUPAC Name:
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
Test material form:
solid
Details on test material:
- Appearance: Light tan solid
- Storage conditions: At room temperature protected from light
Specific details on test material used for the study:
Decomposition during melting (at 195°C).

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Any other information on results incl. tables

Table: Results of the Vapour pressure Isothermal TGA Analysis

Temperature
[°C]

Weight loss
[µg/min]

vT
[g/cm2/h]

log vT

log PT

PT
[Pa]

170

0.441252

5.27E-5

-4.28

-0.34

0.46

 

0.433758

5.18E-5

-4.29

-0.35

0.45

180

1.10311

1.32´E-4

-3.88

0.17

1.5

 

1.04389

1.25E-4

-3.90

0.14

1.4

190

6.40613

7.65E-4

-3.12

1.15

14

 

6.31915

7.54E-4

-3.12

1.14

14

 

The log PT versus 1/T curve for the substance over the range 170 -190°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures. Since the weight loss of the test item at 170°C, 180°C and 190°C was lower than the weight loss of reference substance chrysene at the same temperatures, it was considered that the vapour pressure of the substance at 20°C (25°C) is lower than the vapour pressure of chrysene at 20°C (25°C).

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C was determined to be <8.4E-7 Pa.
The vapour pressure of the substance at 25°C was determined to be <6.6E-7 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. The log PT versus 1/T curve for the substance over the range 170 -190°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures.

From the measured weight losses in the temperature range 170 -190°C, the vapour pressure of the substance was determined to be lower than the vapour pressure of reference substance chrysene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 8.4E-7 Pa and < 6.6E-7 Pa, resp.