Registration Dossier
Registration Dossier
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EC number: 615-206-1 | CAS number: 709031-45-8
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 03 January 2018 to 31 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
- EC Number:
- 615-206-1
- Cas Number:
- 709031-45-8
- Molecular formula:
- C6H10N2O.CH4O3S
- IUPAC Name:
- (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
- Test material form:
- solid
- Details on test material:
- - Appearance: Light tan solid
- Storage conditions: At room temperature protected from light
Constituent 1
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 194.5 °C
- Decomposition:
- yes
- Decomp. temp.:
- 195 °C
- Remarks on result:
- other: Decomposition started during melting.
Any other information on results incl. tables
DSC EXPERIMENT 1
Endothermic peak between 175°C and 200°C (extrapolated onset temperature: 194.505°C) directly followed by an exothermic effect starting at 200°C. The endothermic effect was most likely obtained due to melting of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item. After the experiment, a dark brown molten residue remained in the sample container (original colour: light tan).
DSC EXPERIMENT 2
In order to investigate the melting peak, Experiment 2 was stopped directly after the endothermic peak. Extrapolated onset temperature: 194.545°C. After the experiment, a light yellow molten residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test item.
DATA HANDLING
The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.
Applicant's summary and conclusion
- Conclusions:
- The melting temperature of the substance was determined to be 194.5°C.
- Executive summary:
Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.
The melting temperature of the substance was determined in duplicate obtaining a mean value of 194.5°C. Reaction and/or decomposition of the substance started during melting.
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