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EC number: 615-206-1 | CAS number: 709031-45-8
A study was performed to assess the skin irritation potential of BMS 482204-03 (MSA SALT) to the rabbit. The method followed was that described in: EEC Methods for the determination of toxicity, Annex to Directive 92/69/EEC (Official Journal No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (Skin Irritation). OECD Guideline for Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion". Adopted 17 July 1992.
Three rabbits received a single four hour, semi-occlusive, dermal administration of approximately 0.5 g of the test substance as supplied and were observed for four days.
Very-slight erythema was seen in one animal one hour after bandage removal; no dermal reaction was observed at any other time or in any other animal throughout the duration of the study.The means of scores for these reactions at approximately 24, 48 and 72 hours after administration, calculated separately for each animal. Mean Erthema and Oedema was 0. Classification is triggered if means of scores for either effect are :2: 2 for two or three animals (or if effects persist to Day 14 in at least two animals). BMS was not considered to be irriting in this study
BMS 482204-03 (MSA SALT) did not require labelling with the risk phrase R38, "Irritating to skin", in accordance with Commission Directive 2001/59/EC.
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