Registration Dossier
Registration Dossier
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EC number: 203-697-1 | CAS number: 109-70-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data taken from IUCLID4 report with no information on methods or GLP status.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method FDA modified followed
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- 1-bromo-3-chloropropane
- EC Number:
- 203-697-1
- EC Name:
- 1-bromo-3-chloropropane
- Cas Number:
- 109-70-6
- Molecular formula:
- C3H6BrCl
- IUPAC Name:
- 1-bromo-3-chloropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- Methylcellulose
- Duration of treatment / exposure:
- Once daily
- Frequency of treatment:
- 5 days/week for 10 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25 mg/kg; 75 mg/kg and 125 mg/kg bodyweight
Basis:
- No. of animals per sex per dose:
- 3 groups of 10 males
- Control animals:
- yes
- Positive control(s):
- Triethylenemelamine was given as a positive control orally to a group of 10 male rats at a dose of 0.05 mg/kg.
Examinations
- Tissues and cell types examined:
- The test article did not produce dominant lethal effects in the male rats at the doses administered as measured by pre-implantation and post-implantation losses.
- Evaluation criteria:
- Dominant lethal effects were seen in the positive control group as a significant increase in post-implantation deaths.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Under the conditions of this test, 1-bromo-3-chloropropane was not considered as mutagenic.
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