Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 263-503-6 | CAS number: 62314-25-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 18, 1976 - December 29, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- A group of ten male albino rats was used in this study. The rats were placed in a 70 liter all glass exposure chamber and exposed to a saturated atmosphere of the test material in air for one hour.
The material was administered as an aerosol with particles 3-5 microns in diameter.
The rate of flow was 10.0 liters per minute at a temperature of 71°f (21.67°c).
The air was passed through a desicant prior to being passed through the test material.
By differential weighing it was calculated that the rats were subjected t o a concentration of 7.5 m g / liter during the exposure period. This is an average value over the one hour period. - GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- (2-hydroxypropyl)trimethylammonium formate
- EC Number:
- 263-503-6
- EC Name:
- (2-hydroxypropyl)trimethylammonium formate
- Cas Number:
- 62314-25-4
- Molecular formula:
- C6H16NO.CHO2
- IUPAC Name:
- (2-hydroxypropyl)trimethylammonium formate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Remarks:
- albino
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- > 3 - <= 5 µm
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 7.5 mg / liter
- No. of animals per sex per dose:
- 10 males in one dose group
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 7.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- No mortalities observed after 14 days
- Clinical signs:
- other: No behavioural abnormalities observed.
- Body weight:
- Not recorded
- Gross pathology:
- Gross parthologic examonation of all animal revealed nothing remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study the LC50 for Dabco TMR-2 was found to be greater than 7.5 m g / liter .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
