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EC number: 263-503-6
CAS number: 62314-25-4
Inhalatory N(L)OAEC= oral
This yields a NOECcorr of 1000mg/kg/d*(1/0.38 m3/kg/d)*0.67*(0.5*1)
= 1000 * 2.63 * 0.67 * 0.5
= 881.5 mg/m3= NOECcorr Workers
Based on: How to prepare toxicological summaries in IUCLID and how to
derive DNELs Practical Guide 14
DNELs for acute effects are recommended to be derived if an acute
toxicity hazard (leading to classification and labelling) has been
identifiedandthere is a potential for high peak exposure (R.8.
1.2.5, p. 16). Dabco TMR2 is classified for acute effects of skin and
eye corrosion, and is anticipated to be a respiratory irritant.
Concerning exposure to Dabco TMR2, in the scenarios reported by
users, there may be opportunities for short intermittent dermal or
inhalation exposure in the workplace, such as during sampling or
transferring material. The low vapour pressure of the substance maybe a
mitigating factor in exposures. Oral exposure is deemed unlikely.
According to the ECHA Guidance, Appendix R 8.8, there is “no
accepted methodology for determining acute dermal exposures, and
protection is generally accommodated by more conservative long-term
systemic DNELs” (p. 106).
One well-established method used to estimate an acute threshold
limit value (TLV) is the multiplication of the long-term DNEL by a
factor of 3 (Guidance R.8, Appendix R.8.8, p. 110, 2008, equivalent to
dividing by 0.33 as required in the IUCLID5 format).
Therefore the following Acute Systemic DNELs are derived:
Systemic Inhalation:11.75 x
3 =35.25 mg/m3
It should be noted that, at exposures to these levels, a local
irritant effect may already be obvious to the user. The amelioration of
local skin/eye risks should provide an adequate degree of safety from
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